In May 1963, Topham and his friend at secondary school, Chris Dreja, visited the Railway Hotel in Norbiton. The hotel's entertainment featured traditional jazz music in the upstairs lounge, and allowed budding musicians to play during the breaks. There, he and Dreja met singer and harmonica player Keith Relf, bassist Paul Samwell-Smith, and drummer Jim McCarty and decided to form The Yardbirds, with Topham as lead guitarist. Two weeks later they played their first gig at the Eel Pie Island, supporting the Cyril Davies All-Star Two months after the formation of the Yardbirds, Giorgio Gomelsky offered them the residency at the Crawdaddy Club and became their manager. As the Yardbirds had to turn professional, Topham faced parental disapproval coupled with the anxiety of abandoning his art studies. He could not devote himself to the Yardbirds full-time and he left. His replacement was a fellow art student from the same secondary school, Eric Clapton.
Topham recalls, "I was only 15 then, three or four years younger than the rest, and there was no way my parents would let me go out five or six nights a week to play music, even though I was already bringing home double what my father was earning. I was going on to Epsom Art School and they wanted me to take it seriously. Eric Clapton was the obvious person to replace me. Later on I didn't regret leaving because they'd moved away from the blues music that I was interested in. Even if I'd stayed with them to become professional I think I would have left later for the same reasons Eric left."
He went on to Art College where he formed bands with his friend Duster Bennett. He joined Winston G and the Wicked (later renamed The Fox), playing alongside Marc Bolan, early Yes and Captain Beefheart. After a final gig with Winston G at London's Roundhouse, Topham revived his association with Bennett, recording a live album with him. This led to an introduction to Mike Vernon and his Blue Horizon label. Topham became a session musician for Blue Horizon, playing with Peter Green and Christine McVie. Topham recorded a solo album for Blue Horizon, Ascension Heights. While Bennett was touring with John Mayall in 1970, Topham fell seriously ill and had to abandon the music industry again. Upon his recovery two years later, he entered the fine arts business but a chance meeting with Jim McCarty, led Topham to return to the blues in 1988. The Topham-McCarty Band was formed and played for two years until Topham decided in July 1990 to pursue country blues. He sessioned on 12-string guitar for the track "Broken Waltz Time" on the Bill Morrissey album, Night Train (Philo Records). Later, Topham and Jim McCarty teamed again up for Pete Brown's double album, Rattlesnake Guitar (Coast-to-Coast Records).
In the 2000s, Topham guested with the latest edition of the Yardbirds under the co-leadership of McCarty and Dreja, and performed with John Idan in sporadic concerts of his own.
Top Topham was the only musician I know of from those days in Swanage. Some of the seasonal workers were students coming from different parts of the country (Christine Perfect was from Birmingham). Others were locals living in the Dorset area. Of the Kingston mob, most didn’t have any great ambitions then and were just glad to be away from boring jobs and families in the metropolis. There were a few artists, writers, etc, among us that I knew of, but the majority hadn’t given the future too much serious thought – that would come later. MB – 2011.